Table 5.

Results of the multivariable linear mixed model of log of the ratio between B lymphocytes in absolute number and CD28-CD8+ T cells in absolute number measured at the time of biopsy (Rejection of all types versus normal/subnormal).

	Adjusted mean difference	95% CI	p-value
Rejection of all types vs. normal/subnormal	-0.36	[-0.55; -0.16]	0.0003
Recipient age (years)	0.00	[-0.01; 0.01]	0.7902
Male recipient	-0.05	[-0.22; 0.15]	0.5821
Renal transplantation	0.44	[0.10; 0.81]	0.0162
Delayed graft function	-0.07	[-0.28; 0.12]	0.4845
Retransplantation	-0.42	[-0.72; -0.11]	0.0084
Cold ischemia time (hours)	-0.02	[-0.03; 0.00]	0.0499
Recipient/Donor CMV serology			<0.0001
1 (vs. 0)	-1.37	[-1.61; -1.13]
2 (vs. 0)	-0.68	[-0.93; -0.46]
3 (vs. 0)	-1.28	[-1.56; -1.08]
Donor age (10 years)	-0.01	[-0.02; 0.00]	0.0167
Male donor	-0.13	[-0.31; 0.06]	0.1636
Deceased donor	0.10	[-0.24; 0.49]	0.6097
HLA-A-B-DR mismatches > 4	0.12	[-0.10; 0.34]	0.2887
Depleting induction	0.56	[0.30; 0.77]	<0.0001
Cyclosporine	-2.35	[-4.09; -0.61]	0.0085
Tacrolimus	-1.52	[-3.27; 0.28]	0.0939
mTOR inhibitors	0.43	[-0.36; 1.20]	0.2867
Calcineurin inhibitors	3.63	[1.39; 5.92]	0.0018
Positive anti-class I immunization	-0.08	[-0.26; 0.16]	0.4445
Positive anti-class II immunization	0.07	[-0.15; 0.30]	0.5346
Biopsy rank			<0.0001
2 (vs. 1)	-0.31	[-0.42; -0.16]
3 (vs. 1)	-0.50	[-0.74; -0.22]
4 (vs. 1)	-1.22	[-1.95; -0.51]
5 (vs. 1)	-0.83	[-2.65; 0.97]
For causes biopsy	0.13	[-0.08; 0.29]	0.2085
Creatininemia at biopsy (100 μmol/l)	0.08	[-0.02; 0.18]	0.1030
Post-transplantation time of the biopsy (years)	-0.01	[0.04; 0.03]	0.5394

CI, confidence interval; CMV, cytomegalovirus; Recipient/Donor CMV serology definition. 0, negative donor and recipient; 1, negative donor and positive recipient; 2, positive donor and negative recipient; 3, positive donor and recipient. HLA, human leucocyte antigens; mTOR, mammalian target of rapamycin; Log, natural logarithm.