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. 2023 Apr 24;13:1183442. doi: 10.3389/fonc.2023.1183442

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Copyright © 2023 Choi, Ju, Kang, Seo, Kim, Miyoshi, Yeo and Park

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnostic and prognostic value of EV-Hp fucosylation in CCA. Quantitative data are shown as mean ± S.E.M. Statistical analysis was performed using the two-tailed Student’s t-test. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05, ns, p > 0.05. (A) AAL blotting for EV-Hp of CCA and healthy volunteers. The fucosylation level was examined using a blotting index; n = 7. (B) Comparison of EV-Hp fucosylation for different stages of CCA, inflammatory conditions, and normal. (C) Effect of tumor location on EV-Hp fucosylation. IHCC, intrahepatic cholangiocarcinoma. EHCC, extrahepatic cholangiocarcinoma. (D) Effect of pre- and post-surgery to remove tumors on fucosylation of EV-Hp; n = 5. ns, not significant.