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. 2023 Apr 24;14:1176748. doi: 10.3389/fphys.2023.1176748

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Copyright © 2023 Schubert, Gaynullina, Shvetsova and Tarasova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative recordings of the noradrenaline concentration (A) and active force (B) in response to EFS of sympathetic nerves by rectangular current pulses (85 mA, 0.1 ms) in an experiment on a segment of the rat mesenteric artery (normalized diameter 280 µm). Phentolamine greatly reduces contraction due to the blockade of postjunctional α₁-adrenoceptors but increases the concentration of noradrenaline (NA) due to the blockade of prejunctional α₂-adrenoceptors. In the presence of tetrodotoxin (TTX) contraction and oxidation current completely disappear.