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. 2023 Apr 24;14:1176748. doi: 10.3389/fphys.2023.1176748

FIGURE 2.

FIGURE 2

Effect of NS19504 and IBTX on methoxamine-induced contractions of the rat A. saphena. (A) Normalized tension (normalized to the maximum response of the 1st CRR-see Figure 1) of A. Saphena at different methoxamine concentrations in the absence of BK channel active agents (Control), in the presence of IBTX (IBTX 10−7 M), in the presence of NS19504 (NS19504 6*10−6 M) and in the combined presence of NS19504 and IBTX (NS19504 and IBTX). (B) NS19504 anti-contractile effect in the absence (Control) and presence of IBTX (IBTX 10−7 M). N = 7; * - p < 0.05. Reproduced and modified with permission from (Ma et al., 2020).