FIGURE 4.
GoSlo-SR-5-6 causes concentration dependent relaxations of isometric preparations of rat Gracilis muscle arteries. (A) Example of the effect of GoSlo 5-6 on tension of an isometric vessel preparation at 10–6 M MX-induced tone. Application denotes the time point where GoSlo or vehicle was added. (B) Effect of GoSlo 5-6 on 10–6 M MX-induced contraction. Vessel tension in the absence (time control) and presence of GoSlo 5-6 at 3 × 10−6 M and at 10–5 M (repeated measures ANOVA: con vs. GoSlo 10–5 M - n = 11; p < 0.05; con vs. GoSlo 3 × 10−6 M—n = 8; p < 0.05; GoSlo 10–5 M vs. 3 × 10−6 M - p < 0.05). (C) Effect of GoSlo 5-6 on 10–5 M MX-induced contraction. Vessel tension in the absence (time control) and presence of GoSlo 5-6 at 10–5 M (repeated measures ANOVA: n = 8; p < 0.05). Reproduced and modified with permission from (Zavaritskaya et al., 2020).