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. 2023 Apr 24;14:1176748. doi: 10.3389/fphys.2023.1176748

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Copyright © 2023 Schubert, Gaynullina, Shvetsova and Tarasova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of the mechanism of BK channel contribution to the anti-contractile effect of SNP. (A) Conditions when NO produced only a small decrease in [Ca²⁺]_i: NO induces a PKG-mediated activation of the BK channel that is stronger than the small [Ca²⁺]_i-decrease-mediated deactivation of the BK channel. The overall effect of both is an activation of the BK channel contributing to the reduction of calcium influx; BK channels facilitate NO-induced vasodilation. (B) Conditions when NO produced a considerable decrease in [Ca²⁺]_i: NO induces a PKG-mediated activation of the BK channel that is weaker than the large [Ca²⁺]_i-decrease-mediated deactivation of the BK channel. The overall effect of both is a deactivation of the BK channel opposing the reduction of calcium influx; BK channels limit NO-induced vasodilation. Reproduced and modified with permission from (Schmid et al., 2018).