Table 1.
Baseline characteristics of all fRT treated meningiomas.
| Primary fRT cohort (n = 137) | ||||
|---|---|---|---|---|
| Total | Progression post-fRT | Stable post-fRT | P-value1 | |
| Gender | 137 | 21 | 116 | |
| Male | 39 (28%) | 7 (33%) | 32 (28%) | 0.784 |
| Female | 98 (72%) | 14 (67%) | 84 (72%) | |
| Age at Diagnosis (median [range]) | 58 (16–92) | 58 (47–92) | 59 (16–88) | 0.288 |
| Clinical/radiographic progression pre-fRT | ||||
| Yes | 110 (80%) | 16 (76%) | 94 (81%) | 0.830 |
| No | 27 (20%) | 5 (24%) | 22 (19%) | |
| Location | ||||
| Supratentorial (ST) | 38 (27%) | 8 (38%) | 30 (26%) | 0.375 |
| Anterior fossa | 6 (4%) | 1 (5%) | 5 (4%) | 1 |
| Convexity | 4 (3%) | 1 (5%) | 3 (3%) | 1 |
| Middle fossa | 17 (12%) | 2 (9%) | 15 (13%) | 0.939 |
| Parasagittal/parafalcine | 7 (5%) | 4 (19%) | 3 (3%) | 8.95 × 10−3* |
| Sphenoorbital/Orbital | 4 (3%) | 0 | 4 (3%) | 0.873 |
| Infratentorial (IT) | 42 (31%) | 13 (62%) | 31 (26%) | 3.47 × 10−3* |
| Petroclival/petrous | 25 (19%) | 5 (24%) | 20 (17%) | 0.682 |
| Other posterior fossa | 17 (12%) | 6 (29%) | 11 (9%) | 3.73 × 10−2* |
| Cavernous sinus (CS) | 37 (27%) | 2 (9%) | 35 (30%) | 9.03 × 10−2 |
| Optic nerve sheath (ONS) | 20 (15%) | 0 | 20 (14%) | 8.49 × 10−2 |
| fRT | ||||
| RT technique | ||||
| iMRT | 125 (91%) | 19 (90%) | 106 (91%) | 1 |
| VMAT | 12 (9%) | 2 (10%) | 10 (9%) | 1 |
| GTV in cm3 (median [IQR]) | 11.7 (5.09–29.1) | 19.1 (13.6–47.8) | 9.59 (4.46–24.1) | 2.86 × 10−2* |
| # of patients in each fRT treatment plan | ||||
| 40 Gy/15 Fr | 5 (4%) | 1 (5%) | 4 (3%) | 1 |
| 50 Gy/25 Fr | 76 (56%) | 11 (52%) | 70 (57%) | 0.659 |
| 54 Gy/30 Fr | 53 (38%) | 7 (33%) | 47 (39%) | 0.705 |
| 60 Gy/30 Fr | 3 (2%) | 2 (10%) | 1 (1%) | 0.0919 |
| Salvage therapy | ||||
| Surgery | 4 (3%) | 4 (19%) | ||
| WHO 1 | 3 | 3 | ||
| WHO 2 | 1 | 1 | ||
| Repeat fRT | 5 (3%) | 5 (23%) | ||
| Palliation | 6 (6%) | 6 (29%) | ||
| Observation | 6 (4%) | 6 (29%) | ||
1
P-value from Welch 2-sample T-test for continuous variables or Chi-square test of proportions for categorical variables; RT- radiotherapy; Gy- gray; Fr- fraction; GTV- gross tumour volume; WHO- World Health Organization; fRT- fractionated radiotherapy; SRS- stereotactic radiosurgery; iMRT- intensity-modulated radiation therapy; VMAT- volumetric modulated arc therapy; *p < 0.05.