Figure 3.

Summary of OR. (A) Summary of best OR in ND unfit patients with AML. Table shows a summary of the best efficacy response achieved by all response-evaluable patients. The response-evaluable population comprised all patients enrolled who (1) completed 1 cycle of tamibarotene and had a follow-up assessment of disease status or (2) were withdrawn from the study before completion of cycle 1 because of documented disease progression. Patients listed in the “other” category did not achieve an International Working Group (IWG) response. ∗RARA overexpression was determined in blasts isolated from PBMCs by qRT-PCR assay. The presence of RARA overexpression was characterized as RARA-positive, and the absence of RARA overexpression as RARA-negative; †Disease status was assessed per the revised IWG AML criteria;^13,14 ‡All response-evaluable patients. (B) Association of IWG response with DNA mutations and cytogenetic risk in RARA-positive patients. Data are shown for the 18 RARA-positive response evaluable patients. Cytogenetic risk was assessed per National Comprehensive Cancer Network (NCCN) AML guidelines 2018.¹⁵ The mutation profiles and cytogenetic risk of patients were site reported. Response was assessed per the revised IWG AML criteria.^13,14