Figure 4.

Downregulation of neutral amino acid transporters in Slc5a2^hi proximal tubular cells because of AKI

(A) UMAP plot of clusters of proximal tubular cells colored as in Figure 1.

(B) Bar plots showing the distribution of each cluster of proximal tubular cells in different groups. Groups are shown in different colors.

(C) Dot plot displaying expression patterns of marker genes in subclusters of proximal tubular cells.

(D) Bar diagram showing the enriched GO biological process (GOBP) terms of each subcluster of proximal tubular cells.

(E) Violin plots showing the downregulation of Slc6a19, Slc43a2 and Slc7a8 specifically in PT-1 during AKI. Groups are shown in different colors.

(F) Multiple labeling staining for Slc5a2 (red) and Slc6a19 (green) in kidney tissues from four groups.n = 5, ∗p < 0.05, ∗∗p < 0.01, One-way ANOVA. Scale bar, 200 μm. Data are presented as mean ± SEM.