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. 2023 Apr 7;26(5):106590. doi: 10.1016/j.isci.2023.106590

Figure 1.

Figure 1

Multi-trait GWAS results and effects of endometrial cancer risk variants on traits included in the GWAS

(A) Manhattan plot of the -log10 p values of the Bayes Factor (x-axis; PBF) for endometrial cancer risk (all histologies) of GWAS variants (chromosmal location shown on x-axis). Novel loci are annotated in red text and known risk loci in black. The red line indicates genome-wide significance at p < 5 × 10−8.

(B) Heatmap of prior effects of endometrial cancer risk variants on risk factors included in the bGWAS analysis. Effect alleles of variants are shown. NA: variant not available for trait assessment, asterisk (∗) indicates variant is significantly associated with risk factor (p < 5 × 10−8).