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. 2023 May 7;13(5):e1260. doi: 10.1002/ctm2.1260

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© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Chromosome region maintenance 1 (CRM1) negatively correlates with nuclear expression of BATF2 and colorectal cancer (CRC) prognosis. (A) Bioinformatic analysis of the conserved nuclear export sequence (NES) region (any amino acid) in BATF2 protein in mammals by using BLAST software of national center of biotechnology information (NCBI). (B) Recombinant BATF2 plasmids without mutation (C116) or with leucine mutated into alanine in the NES region (A116) were separately infected into HCT116 cells by using lentivirus. (C and D) Western blot and immunofluorescence analysis of nuclear BATF2 expression in C116 and A116 cells. (E) Co‐immunoprecipitation (co‐IP) analysis of the binding between CRM1 and BATF2 in C116 and A116 cells. Scale bar: 10 µm.