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. 2023 Mar 29;15(5):e16877. doi: 10.15252/emmm.202216877

Figure 3. Silencing of TFEB or TFE3 inhibits the growth of BHD‐associated tumors.

Figure 3

  • A–F
    (A, D) Representative pictures of mice injected with UOK257 cells silenced for luciferase (shLuc) (A, D) or for TFEB (A) or for TFE3 (D). Pictures were taken approximately 4 months after injection. (B, E) Plots show tumor volumes in mice injected with UOK257/shLuc (n = 8) or UOK257/shTFEB (n = 10) (B) and mice injected with UOK257/shLuc (n = 8) or UOK257/shTFE3 (n = 9) (E); (mean ± SD). *P = 0.036 for plot in (B) and *P = 0.023 for plot in (E); unpaired t‐test. (C, F) Kaplan–Meier analysis of mice survival relative to the two experimental groups. Long‐rank test, P < 0.0001. The median survival time of mice injected with UOK257/shLuc is 219.5 days in (C) and 244.5 days in (F).
  • G
    Venn diagram showing overlapping genes in the analyzed data sets.
  • H
    KEGG pathways relative to overlapping genes in (G) (Dataset EV4).

Source data are available online for this figure.