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Histopathology results. (A) Submucosal spindle cell proliferation with diffuse sheets or vague storiform arrangements of bland tumor cells. (B) At higher magnification, there is no nuclear pleomorphism, mitosis or necrosis. (C) KIT (CD117) immunohistochemistry shows intense and diffuse positivity (cytoplasmatic and membrane-associated). (D) Immunohistochemistry for DOG1 (ANO1) is also a sensitive and specific marker and may be helpful in KIT-negative GISTs.
