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. 2023 Apr 24;14:1146496. doi: 10.3389/fmicb.2023.1146496

FIGURE 6.

FIGURE 6

Transposon-insertion sequencing (TIS) analysis of alternative pathways to NER for MMC tolerance. (A) Functional Kmeans clustering of important genes for MMC survival in the uvrA strain. (B) Functional Kmeans clustering of the counter selected genes for MMC survival in the uvrA strain. (C) TIS results in the presence of MMC for a subset of genes involved in oxidative stress tolerance in the WT, recN, and uvrA strains. Results are average of three replicates and analyzed with multiple paired t-test *<0.1. (D) TIS results in the presence of MMC for the subset of E. coli DDR genes in the WT and uvrA strains. Results are average of three replicates and analyzed with multiple paired t-test *<0.1, **<0.05.