TABLE 1.
Dose- and antigen-dependent occurrence of correlations between antibody immune responses in serum and local secretions after mucosal immunization
| OVA dose (mg)a | Rate (%) of significant site-to-site correlationsb among:
|
|||
|---|---|---|---|---|
| Absolute antibody titers against:
|
Relative antibody titers against:
|
|||
| OVA | CT | OVA | CT | |
| 0 | NA | 6.7 (3/45) | NA | 4.4 (2/45) |
| 0.2 | 62.2 (28/45) | 6.7 (3/45) | 55.6 (25/45) | 2.2 (1/45) |
| 2 | 20.0 (9/45) | 6.7 (3/45) | 8.9 (4/45) | 4.4 (2/45) |
| 20 | 2.2 (1/45) | 2.2 (1/45) | 4.4 (2/45) | 4.4 (2/45) |
CT (10 μg) was administered to all groups.
The rate of significant site-to-site correlations is the percentage of significant correlations (P < 0.05, Fisher's r-to-z transformation) among all possible correlations between the samples analyzed. Absolute and relative titers of the following samples were used in the correlation analyses: serum IgA, salivary IgA, urinary IgA, fecal IgA, duodenal IgA, jejunal IgA, ileal IgA, rectal IgA, and vaginal IgA. For serum IgG, absolute titers were used in all calculations. Actual numbers of correlations and the number of all possible permutations are given in parentheses. NA, not applicable.