Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 5;220(8):e20221166. doi: 10.1084/jem.20221166

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 Yang et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 8. — IT rMVA elicits strong antitumor immunity in multiple murine tumor models. (A) Tumor volumes over days in BALB/c mice treated with IT rMVA or PBS control in an A20 B cell lymphoma implantation model. (B) Kaplan–Meier survival curve of mice treated with IT rMVA or PBS (n = 10; ****P < 0.0001, Mantel-Cox test). A representative experiment is shown, repeated once. (C) Tumor volumes over days in the MMTV-PyMT breast tumor model. Data are means ± SD (n = 5; **P <0.01, ***P < 0.001, t test). (D) Representative flow cytometry plots of Granzyme B⁺CD8⁺ T cells in the IT rMVA- or PBS-treated tumors from MMTV-PyMT mice. A representative experiment is shown, repeated twice. (E) Percentages of Granzyme B⁺ CD8⁺ T cells in the rMVA- or PBS-injected tumors. Data are means ± SD (n = 8; ****P < 0.0001, t test). (F) Representative flow cytometry plots of Foxp3⁺CD4⁺ T cells in the rMVA- or PBS-injected tumors. (G) Percentages of Foxp3⁺CD4⁺ T cells in the rMVA- or PBS-injected tumors. Data are means ± SD (n = 8; ***P < 0.001, t test). (H) Schematic diagram of ex vivo infection of human Extramammary Paget’s disease tumors with rhMVA (MVA∆E5R-hFlt3L-hOX40L). (I) Percentages of Granzyme B⁺CD8⁺ T cells and Foxp3⁺CD4⁺ T cells in the rhMVA- or PBS-treated tumor tissues. Data are means ± SD (n = 7; *P < 0.05, **P < 0.01, t test).