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Transcriptomic subtype classifications and surrogate markers of PDAC. Classical tumors are associated with a better patient survival with surrogate markers: GATA6, HNF1A/4A, and PDX. Basal-like tumors have poorer outcomes with surrogate markers: MYC, ΔNTP63, RUNX2, and KRT5/14/17. Hybrid tumors show a mixed character of classical and basal with high plasticity after drug treatment.
