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. 2023 May 8;23:86. doi: 10.1186/s12935-023-02923-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The different interactions of CAR-NKT cells with other immune cells and tumor cells. The CAR-NKT cell, by various methods, can regulate the immune system and lytic the tumors by or not CAR. Also, CAR-NKT cell can activate other immune cells like CD8-, CD4-, and NK-cells, and macrophages-. For instance, CAR-NKT cells can change the immune suppressive macrophages into immune-stimulating macrophages, and by increasing perforin and granzyme B, improve tumor eradication.