Table 1.
| Special | Type 1 NKT | Type 2 NKT | NKT like cell |
|---|---|---|---|
| CD1d dependent | Yes | Yes | No |
| α-GalCer reactive | Yes | No | No |
| TCRa chain | Va14-ja18(mice), va24 ja18(human) | Diverse, but some vas3.2-ja9, Va8(mice) | Diverse |
| NK1.1 or CD161 | Positive (resting mature) | Positive and negative | Positive |
| Restriction | CD1d | CD1d | MHC |
| Subset |
CD4+DN(mice) CD4+CD8+DN(human) |
CD4+ and DN | CD4+, DN, and CD8+ |
| IL-4 production | Yes | Yes | No |
| IFNγ production | Yes | Yes | Yes |
| Development requirements | IL-15 | Not Established | Not Established |
| Tissue location | Liver, spleen, intestine, and pulmonary mucosa | Liver and spleen | Liver, spleen, and bone marrow |
| TCRB chain |
VB2, VB7, VB8.2 (mice) VB11 (human) |
Diverse, but some VB8.2 (mice) | Diverse |