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. 2023 Apr 13;2(5):pgad134. doi: 10.1093/pnasnexus/pgad134

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© The Author(s) 2023. Published by Oxford University Press on behalf of National Academy of Sciences.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — c-Fos⁺ cell counts in hippocampal subfields [total DG, DG hilus, DG granule cell layer (DG GCL), CA3, and CA1]. A) Top: representative sections showing c-Fos expression in AAV-hSyn-DIO-mCherry mice (“mCherry” mice) and AAV-hSyn-DIO-hM4D(Gi)-mCherry mice (“hM4D(Gi)-mCherry” mice) during CCI. Bottom: representative sections showing c-Fos expression in mCherry and hM4D(Gi)-mCherry mice during SCI. B) Left: estimated density of c-Fos⁺ cells in the hM4D(Gi)-mCherry mice after CCI, normalized to the number of c-Fos⁺ cells in the mCherry control mice. Right: estimated density of c-Fos⁺ cells in the hM4D(Gi)-mCherry mice after SCI, normalized to the number of c-Fos⁺ cells in the mCherry control mice. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with the corresponding mCherry control group.