Table 1.
Demographic, clinical and treatment characteristics of pathological stage I-III HR+HER2- breast cancer patients with 1 – 3 positive nodes, NCDB 2004-2018.
| CHARACTERISTICS | Endocrine therapy alone (n=20,940) | Endocrine therapy plus chemotherapy (n= 7,487) | |||
|---|---|---|---|---|---|
| NO. | % | NO. | % | P value | |
| Age, years | 61 (20-90) | 54(32-84) | P<0.001 | ||
| Age≤50 | 3,954 | 18.88 | 2,903 | 38.77 | P<0.001 |
| Age>50 | 16,986 | 81.12 | 4,584 | 61.23 | |
| Oncotype | P<0.001 | ||||
| ≤11 | 7,941 | 37.92 | 1,271 | 16.98 | |
| 12-25 | 12,999 | 62.08 | 6,216 | 83.02 | |
| Race | P=0.045 | ||||
| White | 18,074 | 87.11 | 6,426 | 86.5 | |
| Black | 1,679 | 8.09 | 592 | 7.97 | |
| Asian and other | 996 | 4.8 | 411 | 5.53 | |
| Charlson-Deyo Score | <0.001 | ||||
| 0 | 17,468 | 83.42 | 6,546 | 87.43 | |
| 1 | 2,753 | 13.15 | 779 | 10.4 | |
| 2 | 525 | 2.51 | 130 | 1.74 | |
| 3 | 194 | 0.93 | 32 | 0.43 | |
| Insurance | P<0.001 | ||||
| Public | 8,951 | 43.14 | 1,859 | 25.09 | |
| Private | 11,515 | 55.5 | 5,444 | 73.47 | |
| Not insured | 282 | 1.36 | 107 | 1.44 | |
| Facility Type | P<0.001 | ||||
| Community cancer program | 1,194 | 5.8 | 388 | 5.55 | |
| Comprehensive community cancer program | 8,375 | 40.66 | 2,608 | 37.33 | |
| Academic/research program | 6,480 | 31.46 | 2,488 | 35.61 | |
| Integrated network cancer program | 4,548 | 22.08 | 1,503 | 21.51 | |
| Facility Area | P=0.022 | ||||
| Metro | 17,638 | 86.42 | 6,342 | 87.66 | |
| Urban | 2,503 | 12.26 | 799 | 11.04 | |
| Rural | 269 | 1.32 | 94 | 1.3 | |
| Grade | P<0.001 | ||||
| Well differentiated | 6,382 | 31.46 | 1,574 | 21.82 | |
| Moderately differentiated | 12,193 | 60.1 | 4,516 | 62.61 | |
| Poorly differentiated | 1,703 | 8.39 | 1,120 | 15.53 | |
| Undifferentiated | 10 | 0.05 | 3 | 0.04 | |
| Lymphovascular invasion | P<0.001 | ||||
| Not Present | 12,638 | 69.22 | 3,954 | 60.47 | |
| Present | 5,620 | 30.78 | 2,585 | 39.53 | |
| Positive Nodes | P<0.001 | ||||
| 1 | 16,956 | 80.97 | 5,188 | 69.29 | |
| 2 | 3,200 | 15.28 | 1,666 | 22.25 | |
| 3 | 784 | 3.74 | 633 | 8.45 | |
| Pathological stage | P<0.001 | ||||
| I | 5,366 | 25.99 | 1,108 | 15.05 | |
| II | 14,722 | 71.31 | 5,859 | 79.56 | |
| III | 557 | 2.7 | 397 | 5.39 | |
| Breast Surgery Type | P<0.001 | ||||
| Partial mastectomy | 13,228 | 63.17 | 4,040 | 53.96 | |
| Unilateral mastectomy | 5,208 | 24.87 | 1,998 | 26.69 | |
| Bilateral mastectomy | 2,504 | 11.96 | 1,449 | 19.35 | |
| Axillary Surgery Type | P<0.001 | ||||
| SLNB (1-5 lymph nodes) | 13,410 | 64.14 | 3,895 | 52.08 | |
| ALND (>5 lymph nodes) | 7,499 | 35.86 | 3,584 | 47.92 | |