Table 1.

Demographic, clinical, and post-mortem characteristics stratified by clinical diagnosis

	CU (n = 73)	aMCI (n = 42)	AD (n = 90)	p value
Age at death (years)	87.07 ± 7.47	87.41 ± 7.64	86.91 ± 9.28	0.98
Education (years)	15.19 ± 2.73	15.00 ± 3.04	14.99 ± 2.95	0.72
Sex (male/female)	36/27	27/15	49/41	0.30*
APOE ε4 (carrier/non-carrier)	17/56	6/35	36/51	0.003*
Clinical dementia rating sum of boxes	0.39 ± 0.97	1.80 ± 1.34	12.14 ± 5.61	< 0.001
Mini mental state exam	27.83 ± 1.61	25.68 ± 2.46	16.87 ± 7.43	< 0.001
Alzheimer’s Questionnaire	2.93 ± 4.29	7.79 ± 5.79	22.24 ± 5.74	< 0.001
Post-mortem interval (hours)	5.67 ± 9.10	4.67 ± 4.04	3.44 ± 2.30	0.03
Duration between last clinical assessment and autopsy (months)	12.75 ± 11.67	13.12 ± 10.54	21.88 ± 16.42	< 0.001
Braak Stage (I-II, III-IV, V-VI)	9, 61, 3	2, 35, 5	1, 27, 61	< 0.001*
CERAD neuritic plaque density (none, sparse, moderate, frequent)	15, 16, 8, 34	11, 8, 3, 20	7, 4, 2, 76	< 0.001*
Total tangle score	5.59 ± 2.25	6.55 ± 2.23	10.32 ± 3.49	< 0.001
Total plaque score	6.58 ± 5.56	6.07 ± 5.93	11.28 ± 4.71	< 0.001

CU cognitively unimpaired, aMCI amnestic mild cognitive impairment, AD Alzheimer’s disease; mean ± standard deviation

^*Chi-square p value