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Conventional peptide hydroxamates show varying degrees of selectivity for IDE. Dose-response curves for inhibitors 1a (A), 8a (B), 8b (C) and 14a (D) against IDE, NEP, ECE1, ACE, MMP2 and MMP7. The legend in panel B (inset) applies to all graphs. Note that MMP7 is rather potently inhibited by inhibitors 1a and 8a, but not by inhibitors 8b or 14a.
