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. Author manuscript; available in PMC: 2023 Oct 6.
Published in final edited form as: Nat Med. 2023 Apr 6;29(4):803–810. doi: 10.1038/s41591-023-02276-w

Fig. 2 |. Radiographic changes seen in TIAN.

Fig. 2 |

Three days after receiving tisagenlecleucel to treat a primary CNS lymphoma, a patient developed increased T2/fluid-attenuated inversion recovery (FLAIR) signal surrounding the tumor bed, indicative of cerebral edema, that increased by day 11. These radiographic findings correlated with transient clinical worsening on day 11, which was associated with increased headaches, somnolence, left hemiparesis and left-sided, painful dysesthesias. Both the clinical and the radiographic findings then resolved over time. RT, radiation therapy.