Figure 2.
Performance of MyRF mice in the Morris water maze during the 28 d probe test. A, The MyRF−/− mice spent a smaller percentage of time in the target quadrant compared with the MyRF+/− controls during the 28 d probe test. The MyRFDHF mice that received 7,8-DHF immediately after each training session spent a larger percentage of time in the target quadrant compared with the MyRF−/− mice, indicating rescue of long-term spatial memory by 7,8-DHF. The swim speed of the mice was comparable for all groups during the probe test. B, Percentage of time in the target quadrant and swim speed for male mice. C, Percentage of time in the target quadrant and swim speed for female mice. Data are presented as the mean ± SD. *p < 0.05.