Figure 4.
Increased numbers of new oligodendrocytes in the corpus callosum of MyRF−/− mice following 7,8-DHF administration. Representative images of corpus callosum in MyRF+/−, MyRF−/−, and MyRFDHF mice showing EdU+ cells in yellow, CC1+ cells in magenta, and a merged image. EdU+/CC1+ cells are indicated with arrows. A, The number of EdU+/CC1+ cells was lower in the MyRF−/− mice compared with the group that received 7,8-DHF and the MyRF+/− control group. This indicates that the number of new mature oligodendrocytes was increased by administration of 7,8-DHF in the corpus callosum. B, No difference was seen in the number of EdU+/NeuN+ cells in the dentate gyrus, indicating no change in the numbers of newly formed neurons. Data are presented as the mean ± SD. ***p < 0.001, *p < 0.05.