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. Author manuscript; available in PMC: 2024 Jan 19.
Published in final edited form as: Cell. 2023 Jan 12;186(2):305–326.e27. doi: 10.1016/j.cell.2022.12.027

Figure 3. ICE mice phenocopy brain aging.

Figure 3.

(A) Experimental design.

(B) Ambulatory activity of 10-month post-treated mice in light and dark cycles. Two-way ANOVA-Bonferroni.

(C-E) Immediate and contextual freezing in fear conditioning tests in 10-month post-treated mice. One-way ANOVA-Bonferroni (D, left and E, left) or two-tailed Student’s t test (D, right and E, right).

(F and G) Representative images of Barnes maze tests and mean number of pokes at each hole in 10-month post-treated mice. Two-way ANOVA-Bonferroni.

(H-K) Immunofluorescence of the hippocampal CA3 region stained for astrocyte activation (GFAP) and microglia (IBA1) in 10-month post-treated mice. Scale bar, 100 μm. Two-tailed Student’s t test.

Data are mean ± SEM. n.s.: p > 0.05; *p < 0.05; **p < 0.01; ***p< 0.001; **** p < 0.0001.