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Vaccine efficacy (solid lines) in baseline SARS-CoV-2 seronegative per-protocol vaccine recipients by A) D29 spike IgG or B) D29 receptor binding domain (RBD) IgG in ENSEMBLE by geographic region (US, United States; Lat Am, Latin America; S Afr, South Africa), estimated using the Cox proportional hazards implementation of Gilbert et al.44
