Table 2.
Outcome event rates according to the 24-hour urinary sodium and protein excretion
| Outcomes | Total (N = 967) | Proteinuria <0.5 g/d Urine sodium <3.4 g/d |
Proteinuria <0.5 g/d Urine sodium ≥3.4 g/d |
Proteinuria ≥0.5 g/d Urine sodium <3.4 g/d |
Proteinuria ≥0.5 g/d Urine sodium ≥3.4 g/d |
|---|---|---|---|---|---|
| (n = 239) | (n = 213) | (n = 242) | (n = 273) | ||
| Primary outcome | |||||
| Number of person-y | 3948.2 | 1083.6 | 1021.7 | 841.2 | 1001.8 |
| Number of events (%) | 287 (29.7) | 33 (13.8) | 18 (8.5) | 109 (45.0) | 127 (46.5) |
| Incidence rate | 72.7 | 30.5 | 17.6 | 129.6 | 126.8 |
| All-cause mortality | |||||
| Number of person-y | 4648.7 | 1160.6 | 1055.9 | 1117.8 | 1314.4 |
| Number of events (%) | 49 (5.1) | 9 (3.1) | 11 (5.2) | 19 (7.9) | 10 (3.7) |
| Incidence rate | 10.5 | 7.8 | 10.4 | 17.0 | 7.6 |
CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate.
The primary outcome was defined as CKD progression, which was defined as the first occurrence of a 50% decline in eGFR from the baseline value, or the onset of kidney failure with replacement therapy, and the analysis was performed using a cause-specific model by censoring the death event that occurred before reaching the kidney outcome.