TABLE 2.
Clinicopathologic characteristics of patients undergoing curative gastrectomy for stage I–III gastric cancer based on LVI/PNI status.
| Characteristics | Overall n = 1488 | LVI/PNI | p‐value | |
|---|---|---|---|---|
| (−) n = 736 | (+) n = 752 | |||
| Sex (%) | ||||
| Male | 1001 (67.27) | 493 (66.98) | 508 (67.55) | 0.858 |
| Female | 487 (32.73) | 243 (33.02) | 244 (32.45) | |
| Age (years) (%) | ||||
| <60 | 688 (46.24) | 335 (45.52) | 353 (46.94) | 0.618 |
| ≥60 | 800 (53.76) | 401 (54.48) | 399 (53.06) | |
| BMI (kg/m2) (%) | ||||
| <18.5 | 184 (12.37) | 85 (11.55) | 99 (13.16) | 0.385 |
| ≥18.5 | 1304 (87.63) | 651 (88.45) | 653 (86.84) | |
| HGB (g/L) (%) | ||||
| <90 | 226 (15.19) | 106 (14.40) | 120 (15.96) | 0.445 |
| ≥90 | 1262 (84.81) | 630 (85.60) | 632 (84.04) | |
| ALB (g/L) (%) | ||||
| <35 | 228 (15.32) | 106 (14.40) | 122 (16.22) | 0.366 |
| ≥35 | 1260 (84.68) | 630 (85.60) | 630 (83.78) | |
| CEA (μg/L) (%) | ||||
| ≤5 | 1247 (83.80) | 634 (86.14) | 613 (81.52) | 0.019 |
| >5 | 241 (16.20) | 102 (13.86) | 139 (18.48) | |
| CA199 (U/mL) (%) | ||||
| ≤37 | 1294 (86.96) | 665 (90.35) | 629 (83.64) | <0.001 |
| >37 | 194 (13.04) | 71 (9.65) | 123 (16.36) | |
| CA125 (U/mL) (%) | ||||
| ≤35 | 1418 (95.30) | 706 (95.92) | 712 (94.68) | 0.313 |
| >35 | 70 (4.70) | 30 (4.08) | 40 (5.32) | |
| Tumor location (%) | ||||
| Total | 12 (0.81) | 5 (0.68) | 7 (0.93) | 0.838 |
| Upper | 429 (28.83) | 211 (28.67) | 218 (28.99) | |
| Middle | 323 (21.71) | 155 (21.06) | 168 (22.34) | |
| Lower | 724 (48.66) | 365 (49.59) | 359 (47.74) | |
| pT stage (%) | ||||
| T1 | 339 (22.78) | 309 (41.98) | 30 (3.99) | <0.001 |
| T2 | 171 (11.49) | 113 (15.35) | 58 (7.71) | |
| T3 | 747 (50.20) | 274 (37.23) | 473 (62.90) | |
| T4 | 231 (15.52) | 40 (5.43) | 191 (25.40) | |
| pN stage (%) | ||||
| N0 | 642 (43.15) | 456 (61.96) | 186 (24.73) | <0.001 |
| N1 | 295 (19.83) | 147 (19.97) | 148 (19.68) | |
| N2 | 274 (18.41) | 87 (11.82) | 187 (24.87) | |
| N3 | 277 (18.62) | 46 (6.25) | 231 (30.72) | |
| pTNM_stage (%) | ||||
| I | 407 (27.35) | 365 (49.59) | 42 (5.59) | <0.001 |
| II | 518 (34.81) | 241 (32.74) | 277 (36.84) | |
| III | 563 (37.84) | 130 (17.66) | 433 (57.58) | |
Abbreviations: ALB, albumin; BMI, body mass index; CA, carbohydrate antigen; CEA, carcinoembryonic antigen; HGB, hemoglobin; LVI, lymphovascular invasion; PNI, perineural invasion.