TABLE 4.
Frequency of AEs of any grade or grade 3/4 in patients with ALBI grade 1 versus 2/3.
| Patients, n (%) | AEs of any grade | Grade 3/4 AEs | ||||
|---|---|---|---|---|---|---|
| ALBI grade 1 | ALBI grade 2/3 | p value | ALBI grade 1 | ALBI grade 2/3 | p value | |
| (n = 104) | (n = 106) | (n = 104) | (n = 106) | |||
| Any adverse events | 79 (76.0) | 88 (83.0) | 0.205 | 40 (38.5) | 61 (57.5) | 0.006 |
| Hypertension | 25 (24.0) | 24 (22.6) | 0.811 | 10 (9.6) | 13 (12.3) | 0.539 |
| Skin rash | 8 (7.7) | 6 (5.7) | 0.555 | 4 (3.8) | 2 (1.9) | 0.443 |
| Hand‐foot skin reaction | 18 (17.3) | 31 (29.2) | 0.041 | 8 (7.7) | 11 (10.4) | 0.498 |
| Diarrhea | 30 (28.8) | 29 (27.4) | 0.810 | 12 (11.5) | 17 (16.0) | 0.345 |
| Fatigue | 14 (13.5) | 25 (23.6) | 0.059 | 6 (5.8) | 18 (17.0) | 0.016 |
| Increased blood bilirubin | 38 (36.5) | 51 (48.1) | 0.090 | 15 (14.4) | 34 (32.1) | 0.002 |
| Elevated AST/ALT | 34 (32.7) | 49 (46.2) | 0.045 | 20 (19.2) | 39 (36.8) | 0.005 |
| Thrombocytopenia | 17 (16.3) | 12 (11.3) | 0.318 | 6 (5.8) | 8 (7.5) | 0.606 |
| Decreased appetite | 19 (18.3) | 32 (30.2) | 0.044 | 10 (9.6) | 19 (17.9) | 0.109 |
| Hypothyroidism | 6 (5.8) | 2 (1.9) | 0.168 | 4 (3.8) | 1 (0.9) | 0.210 |
| Pneumonitis | 1 (1.0) | 4 (3.8) | 0.369 | 1 (1.0) | 4 (3.8) | 0.369 |
| Hemorrhage | 4 (3.8) | 2 (1.9) | 0.443 | 4 (3.8) | 2 (1.9) | 0.443 |
Abbreviations: AE, adverse event; ALBI, albumin‐bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase.