Table 3.
Effect of curcumin (CUR) and nano-curcumin (nCUR) on fasting blood glucose value, insulin level, HOMA-IR, and lipid profile of diabetic rats
| Control | Diab | Diab + CUR | Diab + nCUR | |
|---|---|---|---|---|
| FBG (mg/dL) | 86.80b ± 4.25 | 627.4a ± 23.15 | 166.2b ± 42.31 | 157.6b ± 19.85 |
| Insulin (pmol/L) | 71.41a ± 0.47 | 35.41d ± 0.45 | 44.48c ± 0.48 | 60.77b ± 0.43 |
| HOMA-IR | 15.26b ± 0.72 | 54.88a ± 2.27 | 18.15b ± 4.51 | 23.60b ± 2.88 |
| HDL-c (mg/dL) | 53.20a ± 0.86 | 41.00b ± 1.52 | 54.40a ± 1.81 | 56.20a ± 3.94 |
| LDL-c (mg/dL) | 24.40c ± 1.54 | 50.00a ± 4.62 | 38.20b ± 3.69 | 34.80b ± 1.72 |
| TG (mg/dL) | 54.20c ± 2.35 | 86.80a ± 4.28 | 72.20b ± 4.79 | 62.60bc ± 1.36 |
| TC (mg/dL) | 88.20b ± 2.13 | 110.6a ± 2.04 | 107.4a ± 3.44 | 105.4a ± 1.63 |
Each value represents the mean ± SE (n = 5). Values with different superscript letters within the same row are significantly different at P < 0.05. FBG, fasting blood glucose; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; TC, total cholesterol; and TG, triglycerides; Diab, STZ-induced diabetic rats; Diab + CUR, STZ-induced diabetic rats that were given a daily oral dose of 100 mg/kg/day of curcumin were dissolved in carboxymethylcellulose (CMC) 1:10 (w/v); Diab + nCUR, STZ-induced diabetic rats that were given a daily oral dose of 100 mg/kg/day of nano-curcumin were dissolved in carboxymethylcellulose (CMC) 1:10 (w/v)