Fig. 3.

Comparison of model response with experimental data from Johnson et al. (2009) for three different setups: passive response, active response under influence of 1 $\mathrm{\mu }$m Rho kinase inhibitor Y27632 and fully active response. The Rho kinase inhibitor Y27632 is assumed to block the calcium-independent contraction mechanism ($k_{2/5}$ is const.). The results of the model nearly correspond with the experimental data. An adjusted variation of the parameter optimization is illustrated in orange. In this case, the parameter optimization incorporates a decrease of calcium concentration and calcium flow rate while Y27632 influences the artery. The corresponding results are almost identical to the original computation