Table 1.
Characteristics of lung cancer BMs with KPS ≤ 70 stratified by neurosurgical resection
| Characteristics | Unadjusted No. (%) |
PSMa_ajusted No. (%) |
IPTWj_ajusted No. (%) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| No (n = 275) |
Surgery (n = 111) |
P-value | No (n = 68) |
Surgery (n = 68) |
P-value | No (n = 279) |
surgery (n = 110) |
P-value | |
| Age | 0.02 | 0.67 | 0.1 | ||||||
| < 65y | 197 (71.6) | 93 (83.8) | 53 (77.9) | 56 (82.4) | 212 (76.0) | 94 (85.5) | |||
| ≥ 65y | 78 (28.4) | 18 (16.2) | 15 (22.1) | 12 (17.6) | 67 (24.0) | 16 (14.5) | |||
| Gender | 0.49 | 1 | 0.34 | ||||||
| Male | 195 (70.9) | 74 (66.7) | 45 (66.2) | 46 (67.6) | 192 (67.7) | 66 (60.0) | |||
| Female | 80 (29.1) | 37 (33.3) | 23 (33.8) | 22 (32.4) | 87 (32.3) | 34 (40.0) | |||
| Smoking history | 0.01 | 1 | 0.92 | ||||||
| No | 114 (41.5) | 62 (55.9) | 37 (54.4) | 38 (55.9) | 131 (47.0) | 50 (45.5) | |||
| Yes | 161 (58.5) | 49 (44.1) | 31 (45.6) | 30 (44.1) | 148 (53.0) | 60 (54.5) | |||
| Histology | 0.86 | 0.46 | 0.66 | ||||||
| LUADd | 199 (72.4) | 82 (73.9) | 49 (72.1) | 44 (64.7) | 198 (71.0) | 74 (67.3) | |||
| Others | 76 (27.6) | 29 (26.1) | 19 (27.9) | 24 (35.3) | 81 (29.0) | 36 (32.7) | |||
| EGFR/ALK | 0.19 | 0.67 | 0.76 | ||||||
| WTe | 99 (36.0) | 31 (27.9) | 24 (35.3) | 21 (30.9) | 98 (35.1) | 45 (40.9) | |||
| MTf | 75 (27.3) | 29 (26.1) | 22 (32.4) | 20 (29.4) | 71 (25.4) | 27 (24.5) | |||
| NOSg | 101 (36.7) | 51 (45.9) | 22 (32.4) | 27 (39.7) | 110 (39.5) | 38 (44.6) | |||
| Synchronous | 0.004 | 0.72 | 0.96 | ||||||
| No | 119 (43.3) | 30 (27.0) | 21 (30.9) | 24 (35.3) | 109 (39.1) | 42 (38.2) | |||
| Yes | 156 (56.7) | 81 (73.0) | 47 (69.1) | 44 (64.7) | 170(60.9) | 68 (61.8) | |||
| Extracranial metastases | 0.21 | 0.16 | 0.91 | ||||||
| No | 227 (82.5) | 98 (88.3) | 64 (94.1) | 58 (85.3) | 236 (84.6) | 92 (83.6) | |||
| Yes | 48 (17.5) | 13 (11.7) | 4 (5.9) | 10 (14.7) | 43 (15.4) | 18 (16.4) | |||
| Location of BMsh | < 0.001 | 0.52 | 0.95 | ||||||
| Supratentorial | 135 (49.1) | 73 (65.8) | 44 (64.7) | 42 (61.8) | 152 (54.5) | 61 (63.1) | |||
| Subtentorial | 16 (5.8) | 12 (10.8) | 5 (7.4) | 9 (13.2) | 23 (8.2) | 10 (13.8) | |||
| Both | 124 (45.1) | 26 (23.4) | 19 (27.7) | 17 (25) | 104 (37.3) | 29 (23.1) | |||
| Number of BMs | < 0.001 | 0.58 | 0.66 | ||||||
| Single | 62 (22.5) | 46 (41.4) | 20 (29.4) | 24 (35.3) | 78 (28.0) | 28 (25.5) | |||
| Multiplei | 213 (77.5) | 65 (58.6) | 48 (70.6) | 44 (64.7) | 201 (72.0) | 82 (74.5) | |||
| Radiotherapy | < 0.001 | 0.56 | 0.58 | ||||||
| No | 44 (16.0) | 73 (65.8) | 26 (38.2) | 34 (50) | 88 (31.5) | 33 (30) | |||
| WBRT | 90 (32.7) | 27 (24.3) | 30 (44.1) | 23 (33.8) | 82 (29.4) | 29 (26.4) | |||
| SRS | 35 (12.7) | 4 (3.6) | 4 (5.9) | 4 (5.9) | 28 (10.0) | 15 (13.6) | |||
| WBRT + SRS | 106 (38.5) | 7 (6.3) | 8 (11.8) | 7 (10.3) | 81 (29.1) | 33 (30) | |||
| Chemotherapy | 0.004 | 0.73 | 0.68 | ||||||
| No | 106 (38.5) | 61 (55) | 35 (51.5) | 32 (47.1) | 122 (43.7) | 45 (40.9) | |||
| Yes | 169 (61.5) | 50 (45) | 33 (48.5) | 36 (52.9) | 157 (56.3) | 65 (59.1) | |||
| Target therapy or immunotherapy | < 0.001 | 0.49 | 0.87 | ||||||
| No | 111 (40.4) | 70 (63.1) | 40 (58.8) | 35 (51.5) | 136 (48.7) | 55 (50.0) | |||
| Yes | 164 (59.6) | 41 (36.9) | 28 (41.2) | 33 (48.5) | 143 (51.3) | 55 (50.0) | |||
aPropensity score matching; bwhole brain radiotherapy; cstereotactic radiosurgery; dlung adenocarcinoma; ewild type; fmutation; gunknown or untested; hbrain metastases, inumber of BMs ≥ 2; j Inverse probability treatment weighting