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. 2023 Apr 3;55(4):755–766. doi: 10.1038/s12276-023-00981-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Several genes that are involved in signal transduction produce alternative splicing-derived proteins with differential activities in regulating signaling pathways. A brief mechanism of intracellular signal transduction and representative alternative splicing events that regulate them are presented. The seven major signal transduction pathways include the Hedgehog pathway (a), Hippo pathway (b), JAK-STAT pathway (c), NF-κB pathway (d), NOTCH pathway (e), TGF-β pathway (f), and Wnt/β-catenin pathway (g).