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. 2023 Apr 25;14:1166212. doi: 10.3389/fimmu.2023.1166212

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Copyright © 2023 Thompson, Tsaava, Rishi, Nadella, Mishra, Tuveson, Pavlov, Brines, Tracey and Chavan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selective activation of DMN cholinergic neurons reduces serum amylase levels during pancreatitis through a nAChR-dependent mechanism. (A) One hour prior to induction of acute pancreatitis, ChAT-ChR2-YFP mice underwent intraperitoneal injection of vehicle or mecamylamine (1 mg/kg) was injected one hour prior followed by the induction of pancreatitis and optogenetic stimulation. The mice were euthanized 4 hours after the final dose of caerulein. (B) Optogenetic stimulation with blue light (473 nm, 20 Hz, 25% duty cycle, 8-12 mW, 5 minutes) of the DMN significantly decreases the level of serum amylase compared to no stimulation in the vehicle-treated mice but not in animals receiving mecamylamine. Data are represented as individual mouse data points with mean ± SEM. One-way ANOVA, (**P ≤ 0.01, ***P ≤ 0.001, n = 10, ns, not significant.).