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. 2023 May 8;14:2642. doi: 10.1038/s41467-023-38171-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Macrophage polarization-associated intercellular signaling protein expressed by mesenchymal or classical PDAC cells in co-culture with corresponding receptors detected in BMM proteomes. Ligands with significantly different secretion among PDAC subtypes (two-sided Student’s t-test, permutation-based FDR = 0.05, S0 = 0.1) and BMM receptors with significantly different levels of abundance between culture conditions (ANOVA, permutation-based FDR = 0.05, S0 = 1) are indicated in bold. b Heatmaps of primarily macrophage and neutrophil chemoattractants secreted by PDAC cells and BMMs. c Macrophage and neutrophil count as a percentage of CD45-positive cells in tumors from orthotopically transplanted classical and mesenchymal cancer cells analyzed by flow cytometry. Numbers of biological replicates and two-sided Welch’s t-test p-values between cell ratios in classical or mesenchymal tumors are indicated. Source data are provided as a Source Data file.