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. 2023 May 8;14:2644. doi: 10.1038/s41467-023-38279-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Manhattan Plot of DISH GWAS. Associations reaching genome-wide significance below p value < 5e⁻⁸ were labeled. The p value is the two-tailed test for association of trait with variant. B Genetic correlation between DISH and other phenotypes derived from DXA scans, estimated using LD score regression from UK Biobank summary statistics. C GDF5 locus showing a clear overlap of genome-wide significant signals with DISH, Osteoarthritis (OA), and lung Forced Expiratory Volume in one second (FEV1). The p value is the two-tailed test for association of trait with variant.