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. 2023 May 8;9:150. doi: 10.1038/s41420-023-01422-0

Fig. 1. The downregulation of MALAT1 and GATA4 was observed in the bone tissues of PMOP patients and OVX mice.

Fig. 1

A, B The levels of MALAT1 and GATA4 in the bone tissues of PMOP patients were evaluated by qRT-PCR. n = 16. C The correlation of MALAT1 and GATA4 was analyzed by Pearson correlation coefficients. D, E The levels of MALAT1 and GATA4 in the bone tissues of mice treated with ovariectomy (OVX). F, G The mRNA and protein levels of Runx1 in the bone tissues of mice treated with OVX were measured by qRT-PCR and Western blotting. H, I Human BMSCs isolated from bone marrow specimens were cultured into osteogenic-inducing medium for 0, 7, 14 days, and then qRT-PCR analyzed MALAT1 and GATA4 levels in the process of osteogenic differentiation of BMSCs. J The protein expression of Runx1 in the process of osteogenic differentiation of BMSCs. Mean ± SD, n = 3, *p < 0.05, **p < 0.01, ***p < 0.001. Statistical analysis was carried out by a student t-test or a one-way ANOVA.