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. 2023 Apr 3;55(4):779–793. doi: 10.1038/s12276-023-00961-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Western blot analysis of SAMHD1 expression in normal renal epithelial cells (HK-2) and different RCC cell lines (Caki-1, Caki-2, SN12C, ACHN). Densitometric analysis of SAMHD1 protein expression levels relative to β-actin levels. b, c Wound-healing analysis of cell migration ability in SAMHD1-knockdown ACHN and SN12C cells or SAMHD1-overexpressed Caki-1 and Caki-2 cells over 24 h. Data are presented as the mean ± SD. The data shown are representative of three independent experiments. **p < 0.01; ***p < 0.001. d, e Transwell migration assay of cell migration capacity upon SAMHD1 knockdown in ACHN and SN12C cells or overexpression in Caki-1 and Caki-2 cells over 24 h. Data are presented as the mean ± SD. The data shown are representative of three independent experiments. ***p < 0.001. f, g Analysis of cell invasion ability upon SAMHD1 knockdown in ACHN and SN12C cells or overexpression in Caki-1 and Caki-2 cells. *p < 0.05; ***p < 0.001. Data are presented as the mean ± SD of three independent experiments.