Table 3. Combined effect size of each parameter of dual-energy computed tomography.
| Parameter | Sensitivity | Specificity | PLR | NLR | DOR | AUC | Spearman correlation | P value |
|---|---|---|---|---|---|---|---|---|
| IC in AP | 0.77 (0.70–0.83) | 0.78 (0.70–0.84) | 3.42 (2.32–5.04) | 0.3 (0.22–0.43) | 12.01 (5.73–25.16) | 0.84 | –0.429 | 0.397 |
| NIC in AP | 0.78 (0.69–0.86) | 0.79 (0.66–0.88) | 3.49 (2.19–5.57) | 0.29 (0.19–0.46) | 13.74 (5.48–34.45) | 0.85 | –0.042 | 0.907 |
| Slope in AP | 0.74 (0.65–0.82) | 0.85 (0.72–0.93) | 4.12 (2.50–6.77) | 0.32 (0.22–0.47) | 13.82 (6.46–25.96) | 0.85 | −1.017 | 0.819 |
| IC in VP | 0.80 (0.73–0.86) | 0.84 (0.79–0.88) | 4.58 (3.52–5.98) | 0.23 (0.15–0.36) | 21.89 (11.90–40.28) | 0.86 | −0.429 | 0.289 |
| NIC in VP | 0.83 (0.74–0.89) | 0.78 (0.74–0.82) | 3.54 (2.93–4.26) | 0.24 (0.18–0.34) | 15.85 (10.21–24.63) | 0.85 | 0.098 | 0.762 |
| Slope in VP | 0.75 (0.66–0.83) | 0.87 (0.79–0.92) | 5.26 (3.59–7.72) | 0.29 (0.22–0.39) | 20.75 (11.63–37.04) | 0.88 | 0.345 | 0.308 |
| IC in AP + NIC in AP | 0.95 (0.78–0.99) | 0.66 (0.44–0.82) | 2.59 (1.76–3.81) | 0.11 (0.02–0.51) | 21.00 (11.69–37.70) | 0.88 | 0.7 | 0.188 |
| NIC in AP + slope in AP | 0.94 (0.86–0.98) | 0.74 (0.52–0.88) | 3.52 (1.99–6.24) | 0.10 (0.04–0.27) | 38.86 (9.00–167.66) | 0.94 | −0.371 | 0.468 |
| NIC in AP + NIC in VP | 0.95 (0.91–0.98) | 0.60 (0.49–0.70) | 2.4 (1.84–3.13) | 0.09 (0.05–0.18) | 29.54 (12.78–68.27) | 0.9 | 0 | 1 |
| NIC in AP + slope in VP | 0.93 (0.88–0.97) | 0.73 (0.57–0.84) | 3.39 (2.22–5.18) | 0.10 (0.05–0.21) | 37.02 (13.05–105.02) | 0.93 | −0.086 | 0.872 |
| Slope in AP + NIC in VP | 0.95 (0.89–0.97) | 0.66 (0.56–0.75) | 2.75 (2.05–3.68) | 0.09 (0.04–0.20) | 31.89 (13.69–74.24) | 0.88 | 0.029 | 0.957 |
| Slope in AP + slope in VP | 0.92 (0.88–0.95) | 0.74 (0.61–0.83) | 3.25 (2.40–4.41) | 0.12 (0.07–0.19) | 32.00 (15.04–68.09) | 0.93 | 0.036 | 0.939 |
| IC in VP + NIC in VP | 0.97 (0.92–0.99) | 0.69 (0.62–0.75) | 2.97 (2.42–3.65) | 0.05 (0.02–0.15) | 53.29 (20.16–140.83) | 0.82 | −0.072 | 0.878 |
| Slope in VP + slope in VP | 0.96 (0.89–0.99) | 0.68 (0.61–0.74) | 2.85 (2.17–3.75) | 0.07 (0.03–0.20) | 41.03 (14.83–113.54) | 0.77 | −0.486 | 0.329 |
| NIC in VP + slope in VP | 0.95 (0.90–0.97) | 0.68 (0.62–0.74) | 2.94 (2.48–3.48) | 0.10 (0.06–0.17) | 31.23 (18.39–53.04) | 0.85 | 0.433 | 0.244 |
PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; AUC, area under curve; IC, iodine concentration; AP, arterial phase; NIC, normalized iodine concentration; VP, venous phase.