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A
The conversion of succinate to fumarate, which is part of complex II of the ETC and of the TCA cycle, is carried out by succinate dehydrogenase. Diagram showing that succinate dehydrogenase is composed of the OR genes sdha‐1 and sdha‐2 that each function together with the rest of the genes as AND genes. The GPR of this reaction is noted as [(sdha‐1 | sdha‐2) & sdhb‐1] & mev‐1 & sdhd‐1]. Color legend is indicated.
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B
Example of a gene family (aagr) where members occur as paralogous OR gene pairs in separate reactions. Pairs of paralogs associated with different reactions are called other paralogs.
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C
Violin plot comparing coexpression for different populations of gene pairs including random, AND, OR, operon and other paralogs gene pairs in compendium of expression datasets.
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D, E
Percentages of AND, OR, other paralogs, operon genes and random metabolic gene pairs categorized as coexpressed using different coexpression values as cutoffs across developmental time (D) and tissues (E). Color legend as indicated in (D).
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F–H
Violin plots showing coexpression of random gene pairs, all pathway genes, PW genes and PO genes across compendium (F), different developmental stages (G) and tissues (H).
