Table 2.
Univariate and multivariate analyses of factors associated with liver failure after TACE.
| Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|
| Variables | OR (95%CI) | P value | OR (95%CI) | P value | |
| Age (years) | 1.033 (0.988, 1.080) | 0.151 | |||
| Sex (female) | 2.571 (0.644, 10.270) | 0.181 | |||
| HBV (positive) | 1.098 (0.251, 4.810) | 0.901 | |||
| hypertension (yes) | 1.920 (0.452, 8.154) | 0.377 | |||
| Cirrhosis (yes) | 0.793 (0.261, 2.408) | 0.683 | |||
| Portal hypertension (yes) | 0.693 (0.231, 2.076) | 0.512 | |||
| Hemorrhagic Shock (yes) | 4.242 (1.207, 14.908) | 0.024 | NS | ||
| Hb (g/L) | 0.968 (0.945, 0.992) | 0.009 | NS | ||
| PLT (109/L) | 1 (0.996, 1.004) | 0.983 | |||
| Scr (μmol/L) | 1.021 (0.999, 1.043) | 0.064 | NS | ||
| Na (mmol/L) | 1.1 (0.938, 1.29) | 0.24 | |||
| PTA (%) | 0.937 (0.902, 0.972) | 0.001 | 0.956 (0.920, 0.994) | 0.024 | |
| INR | 46.311 (3.609, 594.254) | 0.003 | NS | ||
| PT (s) | 1.683 (1.232, 2.3) | 0.001 | NS | ||
| ALB (g/L) | 0.863 (0.759, 0.981) | 0.024 | NS | ||
| TB (μmol/L) | 1.033 (0.996, 1.071) | 0.083 | NS | ||
| ALT (U/L) | 1.005 (0.999, 1.011) | 0.133 | |||
| AST (U/L) | 1.002 (1, 1.004) | 0.122 | |||
| AFP (<200 ng/mL) | 0.911 (0.296, 2.804) | 0.872 | |||
| Diameter (cm) | 1.047 (0.923, 1.188) | 0.477 | |||
| Number (multiple) | 3.239 (0.917, 11.443) | 0.068 | NS | ||
| Portal vein invasion (yes) | 1.15 (0.386, 3.426) | 0.802 | |||
| Hepatic vein invasion (yes) | 1.808 (0.559, 5.847) | 0.322 | |||
| Extrahepatic metastasis (yes) | 0.12 (0.014, 0.995) | 0.049 | NS | ||
| Time (≥24 h) | 2.148 (0.711, 6.493) | 0.175 | |||
| Embolic agents (DEB) | 0.948 (0.251, 3.577) | 0.937 | |||
| Child-Pugh grade (B) | 14.733 (2.983, 72.759) | 0.001 | 6.419 (1.123, 36.677) | 0.037 | |
| ALBI score | 13.916 (2.435, 79.547) | 0.003 | NS | ||
| MELD score | 1.17 (1.051, 1.303) | 0.004 | NS | ||
| MELD-Na score | 1.117 (1.025, 1.217) | 0.012 | NS | ||
TACE, transcatheter arterial chemoembolization; Hb, hemoglobin; PLT, platelet count; Scr, serum creatinine; Na, serum sodium; PTA, prothrombin activity; INR, international standardized ratio; PT, prothrombin time; ALB, albumin; TB, total bilirubin; ALT, alanine aminotransferase; AST, glutamate transaminase; AFP, alpha-fetoprotein; ALBI, albumin-bilirubin; MELD, model for end-stage liver disease; MELD-Na, model for end-stage liver disease with sodium; DEB, drug-eluting beads; OR, odds ratio; CI, confidence interval; NS, not significant.