Figure 1. Process Used to Interpret National Lung Screening Trial Screening Examinations During the Course of the Trial, Assess Abnormalities Observed, and Assign a Final Diagnosis.

Abnormalities highlighted were reported for screening examinations with a final diagnosis of a negative screen result, significant abnormalities not suspicious for lung cancer or positive screen result, nodule(s) or other nonspecific abnormalities suspicious for lung cancer were considered significant incidental findings; and their descriptions were examined in this study. LDCT indicates low-dose computed tomography; SIF, significant incidental finding.