| 1 |
A high proportion of BC physician respondents would prescribe extended AET with AI beyond 5 years for postmenopausal females with BC. |
| 2 |
For low-risk patients, 5 years of AET is acceptable, but a more experienced physician tends to take a more conservative approach and prescribes a longer duration of AET. |
| 3 |
For intermediate- to high-risk patients, the optimal duration is unknown but 7−8 years of AET appears to be the “sweet spot”. |
| 4 |
For high-risk patients, at least 10 years of AET may be warranted. |
| 5 |
Intermittent letrozole can be considered for low-risk patients, especially for those with potentially poor adherence to extended AET. |
| 6 |
Adjuvant chemotherapy should be prescribed to genomic high-intermediate risk females aged 50 years or younger regardless of the clinical risk classification. |