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. 2023 Apr 30;35(2):140–162. doi: 10.21147/j.issn.1000-9604.2023.02.05

Figure S4.

Figure S4

Relationship between rs8400 G>A and ALKBH5 expression was analyzed by cis-eQTL. (A) Compared with rs8400 G genotype, individuals with rs8400 A allele had significantly higher ALKBH5 mRNA levels in the whole blood and adrenal gland, with consistent results in other tissues (cerebral cortex, tibial nerve, cervical vertebra C1 of the spinal cord and cultured fibroblasts); (B) RT-qPCR results showed that mRNA expression of ALKBH5 in cell lines overexpressing rs8400 A allele was higher than that in cell lines overexpressing rs8400 G allele or control vector; (C) Western blotting results showed that in cell lines overexpressing rs8400 A allele, the protein expression of ALKBH5 was higher than that in the cell lines overexpressing rs8400 G or the control vector. eQTL, expression quantitative trait loci. ****, P<0.0001.