Table 4.
Description of the diabetic outcome-SNP association in the two-sample MR (Coefficient values and standard errors)
| SNP | Outcome | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fasting glucose | HbA1c | |||||||||
| n | β | se | Population | Consortium | n | β | se | Population | Consortium | |
| rs4861163 | 133 010 | 0·004 | 0·002 | European | MAGIC | 46 368 | –0·004 | 0·004 | European | MAGIC |
| rs10822145 | 133 010 | –0·005 | 0·002 | European | MAGIC | 46 368 | 0·001 | 0·003 | European | MAGIC |
| rs6756297 | 58 074 | –0·003 | 0·008 | European | MAGIC | 46 368 | –0·003 | 0·009 | European | MAGIC |
| HOMA-IR | Fasting insulin | |||||||||
| rs4861163 | 37 037 | 0·004 | 0·005 | European | MAGIC | 51 750 | 0·004 | 0·003 | European | MAGIC |
| rs10822145 | NA | NA | NA | NA | NA | 51 750 | –0·006 | 0·004 | European | MAGIC |
| rs6756297 | 37 037 | 0·004 | 0·010 | European | MAGIC | 51 750 | –0·002 | 0·008 | European | MAGIC |
SNP, single-nucleotide polymorphism; MR, Mendelian randomisation; HOMA-IR, homeostatic model assessment for insulin resistance.