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. Author manuscript; available in PMC: 2023 May 9.
Published in final edited form as: Hypertension. 2022 Sep 21;79(11):2552–2564. doi: 10.1161/HYPERTENSIONAHA.122.19557

Figure 2. Properties and number of calcium bursts are equivalent between zona glomerulosa (zG)-TWIK-related acid-sensitive potassium channel (TASK)-loss-of-function (LOF) and AngII (angiotensin II)-stimulated zG cells.

Figure 2.

Distribution and mean duration (A and B) and intraburst frequency (C and D) of calcium bursts in zG cells from zG-TASK-LOF (zT1T3; n=103 cells from 6 mice; black symbols) and 3 nM AngII-stimulated WT (n=102 cells from 6 mice; orange symbols) slices. The distribution (E) and mean (F) number of bursts in the late phase (last 5 minutes of each recording) was invariant across genotype (WT vs zG-TASK-LOF) and AngII concentrations. zG-TASK-LOF+0 pM (n=102 cells from 6 mice; black symbols), 50 pM (n=52 cells from 4 mice; blue symbols), 3 nM (n=101 cells from 6 mice; orange symbols, top), or 3 μM AngII (red; E, n=67 cells from 3 mice, red symbols), and WT slices+3 nM AngII n=100 cells from 6 mice, orange symbols, bottom). Data are expressed as median+25–75 percentile (A, C, E) or mean±SEM (B, D, F); ***P<0.001 or nonsignificant (NS) by linear mixed model with Bonferroni’s multiple comparisons test.