Summary of findings 3. Pharmacologic intervention compared to another pharmacologic intervention for individuals with alcohol use disorder.

Pharmacologic intervention compared to another pharmacologic intervention for individuals with alcohol use disorder
Patient or population: individuals with alcohol use disorder Setting: Low‐ and middle‐income countries Intervention: Pharmacologic intervention Comparison: another pharmacologic intervention
Outcomes	№ of participants (studies) Follow‐up	Certainty of the evidence (GRADE)	Relative effect (95% CI)	Anticipated absolute effects* (95% CI)
				Risk with another pharmacologic intervention	Risk difference with Pharmacologic intervention
Harmful alcohol use ‐ not measured	‐	‐	‐	‐	‐
Retention	190 (2 RCTs)	⊕⊕⊝⊝ Low 1	RR 0.95 (0.76 to 1.19)	Study population
				873 per 1,000	44 fewer per 1,000 (209 fewer to 166 more)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval;RR: risk ratio.
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

¹ Differences in comparators