Summary of findings 4. Pharmacologic intervention compared to another pharmacologic intervention in addition to psychosocial intervention for individuals with alcohol use disorder.

Pharmacologic intervention compared to another pharmacologic intervention in addition to psychosocial intervention for individuals with alcohol use disorder
Patient or population: individuals with alcohol use disorder Setting: Low‐ and middle‐income countries Intervention: Pharmacologic intervention Comparison: another pharmacologic intervention in addition to psychosocial intervention
Outcomes	№ of participants (studies) Follow‐up	Certainty of the evidence (GRADE)	Relative effect (95% CI)	Anticipated absolute effects* (95% CI)
				Risk with another pharmacologic intervention in addition to psychosocial intervention	Risk difference with Pharmacologic intervention
Harmful alcohol use ‐ not measured	‐	‐	‐	‐	‐
Retention	200 (2 RCTs)	⊕⊕⊝⊝ Low 1	RR 1.02 (0.96 to 1.08)	Study population
				940 per 1,000	19 more per 1,000 (38 fewer to 75 more)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio.
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.

¹ Different comparators